{"id":3797,"date":"2020-12-23T13:09:34","date_gmt":"2020-12-23T16:09:34","guid":{"rendered":"https:\/\/acrisure.com.br\/insights\/?p=3797"},"modified":"2026-02-03T11:44:54","modified_gmt":"2026-02-03T14:44:54","slug":"mutacoes-do-coronavirus","status":"publish","type":"post","link":"https:\/\/acrisure.com.br\/insights\/mutacoes-do-coronavirus\/","title":{"rendered":"Muta\u00e7\u00f5es do Coronav\u00edrus: Qual o impacto na vacina\u00e7\u00e3o?"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Post” _builder_version=”4.20.0″ custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_row admin_label=”Post” _builder_version=”4.19.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Conte\u00fado” _builder_version=”4.27.3″ _module_preset=”default” text_letter_spacing=”1px” custom_margin=”||||false|false” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

O SARS-CoV-2, famoso Coronav\u00edrus, \u00e9 um v\u00edrus de RNA. Isso significa que seu material gen\u00e9tico se encontra armazenado em uma \u00fanica fita codificadora. O processo de replica\u00e7\u00e3o dessa fita n\u00e3o \u00e9 perfeito e, \u00e0 medida que altera\u00e7\u00f5es n\u00e3o reparadas acontecem, surgem as muta\u00e7\u00f5es.<\/p>\n

Outros v\u00edrus, como da gripe e o HIV<\/a>, tamb\u00e9m sofrem mudan\u00e7as ao se multiplicar. O coronav\u00edrus, para se ter ideia, sofre modifica\u00e7\u00f5es com metade da velocidade do v\u00edrus da gripe e apenas um quarto da velocidade do HIV. Ou seja, a taxa de muta\u00e7\u00e3o demonstra ser menor.<\/p>\n

Muta\u00e7\u00f5es do coronav\u00edrus: o que elas significam?<\/h4>\n

Desde o in\u00edcio da pandemia, foram identificadas mais de 12 mil muta\u00e7\u00f5es no genoma do SARS-CoV-2. Boa parte delas n\u00e3o s\u00e3o capazes de alterar sua composi\u00e7\u00e3o final, logo, n\u00e3o apresentam perigo. J\u00e1 uma parcela menor dessas muta\u00e7\u00f5es \u00e9 capaz de alterar a estrutura de prote\u00ednas que o comp\u00f5em. Transforma\u00e7\u00f5es como essa ajudaram o v\u00edrus a “saltar” de animais, como morcegos, para humanos.<\/p>\n

Outra muta\u00e7\u00e3o, chamada D614G, altera a prote\u00edna Spike: presente na superf\u00edcie do coronav\u00edrus, ela auxilia a entrada dele nas c\u00e9lulas e facilita seu reconhecimento pelo sistema imunol\u00f3gico. Essa muta\u00e7\u00e3o pode estar relacionada a uma identifica\u00e7\u00e3o menor do v\u00edrus pelo nosso sistema imune, dificultando sua elimina\u00e7\u00e3o, e j\u00e1 \u00e9 dominante no continente europeu e outros pa\u00edses desde abril de 2020.<\/p>\n

Na Inglaterra, em dezembro, identificaram a N501Y, que gera uma nova altera\u00e7\u00e3o na prote\u00edna Spike, possivelmente, associada a maior transmissibilidade da doen\u00e7a, mas n\u00e3o a maior agressividade dela. Por\u00e9m, essa rela\u00e7\u00e3o ainda n\u00e3o est\u00e1 confirmada. A muta\u00e7\u00e3o foi encontrada em lugares com baixos n\u00edveis de isolamento social, o que pode ter facilitado a transmiss\u00e3o.<\/p>\n

Muta\u00e7\u00f5es n\u00e3o s\u00e3o amea\u00e7a para vacinas<\/h4>\n

Apesar dessas muta\u00e7\u00f5es estarem relacionadas a Spike \u2013 alvo das principais vacinas contra a Covid-19 \u2013 a imuniza\u00e7\u00e3o tem na mira diversos segmentos da prote\u00edna, o que garante sua efici\u00eancia caso algum deles seja alterado. Entretanto, muta\u00e7\u00f5es podem se acumular, reduzindo a efic\u00e1cia da vacina e demandando altera\u00e7\u00f5es. Semelhante ao que acontece com a vacina da gripe, que \u00e9 adaptada anualmente.<\/p>\n

Uma pesquisa, recentemente, identificou uma nova vers\u00e3o do SARS-CoV-2 no Rio de Janeiro<\/a>, contendo cinco muta\u00e7\u00f5es em seu material gen\u00e9tico. O estudo, que ainda passar\u00e1 por revis\u00e3o, n\u00e3o confirma se a mudan\u00e7a torna o v\u00edrus mais agressivo ou contagioso. Mas, tamb\u00e9m, n\u00e3o h\u00e1 ind\u00edcios de que o torne resistente \u00e0s vacinas produzidas at\u00e9 o momento.<\/p>\n

Tendo em vista que a vacina\u00e7\u00e3o, apesar de apresentar dados robustos de seguran\u00e7a e efic\u00e1cia, ainda n\u00e3o est\u00e1 amplamente dispon\u00edvel, o distanciamento social e cuidados individuais<\/a> (incluindo higieniza\u00e7\u00e3o frequente das m\u00e3os e uso de m\u00e1scaras) seguem como as medidas mais efetivas para reduzir o n\u00famero de casos da Covid-19.<\/p>\n

\n

Tamb\u00e9m pode interessar:<\/strong><\/p>\n

Comorbidades que agravam risco de complica\u00e7\u00f5es da Covid-19<\/a><\/p>\n

Reinfec\u00e7\u00e3o por Covid-19 \u00e9 poss\u00edvel? Tudo o que voc\u00ea precisa saber<\/a><\/p>\n<\/blockquote>\n

FONTES:\u00a0<\/strong>Revista Nature<\/a>,\u00a0Revista The BM<\/a>, CDC<\/a>, Fiocruz<\/a><\/p>\n

\n\t\t\t\t\t
Siga a It\u2019sSeg no\u00a0LinkedIn<\/a>\u00a0e fique por dentro das novidades do Portal RH!<\/div><\/div>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Muta\u00e7\u00f5es do coronav\u00edrus foram encontradas na Europa e, recentemente, no Brasil. O que isso significa e como impacta as vacinas?<\/p>\n","protected":false},"author":1,"featured_media":3799,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[15],"tags":[20],"class_list":["post-3797","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saude","tag-bem-estar"],"yoast_head":"\nMuta\u00e7\u00f5es do Coronav\u00edrus: Qual o impacto na vacina\u00e7\u00e3o? - Insights \/ Acrisure<\/title>\n<meta name=\"description\" content=\"Muta\u00e7\u00f5es do coronav\u00edrus: entenda como surgem, seus impactos na transmiss\u00e3o e efic\u00e1cia das vacinas contra elas.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/acrisure.com.br\/insights\/mutacoes-do-coronavirus\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Muta\u00e7\u00f5es do Coronav\u00edrus: Qual o impacto na vacina\u00e7\u00e3o? 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